So on the show the Rossum Corporation serves as a stand-in for pretty much all of human society as it is today--programming us in ways that keep us down, essentially. And we also know that it's going to bring about the end of civilization within the next ten years.
And then there's the main characters on the show, who are fighting the Rossum Corporation (aka society, remember) from within and trying to gain an independent identity--in other words, trying to bring about an end to civilization from inside of it. In so doing, they are fighting to prevent the end of civilization.
I don't really understand how corporate media manages to produce art that is not only good but important and actually relevant, but every once in a while it does. Dollhouse is one of these times.